Kenneth C. Ehrlich

The paper shows that promoter-adjacent DNA hypermethylation in TBX15 reduces gene expression in myoblasts and skeletal muscle without silencing it, suggesting a regulatory role in preventing overexpression.

The paper prioritizes regulatory SNPs from obesity GWAS by analyzing epigenomic and transcriptomic features in adipose tissue, identifying 47 potential causal SNPs across 14 genes.

The paper examines the epigenetic regulation and expression of five fibrosis-related genes in cardiac fibrosis, identifying super-enhancers and enhancer chromatin features associated with their expression.

The paper examines the epigenetic features and expression patterns of 21 skeletal muscle-associated genes from four families, identifying tissue-specific regulatory elements and potential regulatory lncRNAs.

The paper identifies regulatory SNPs in TBX15 that influence both obesity and osteoporosis risk through epigenetic and genetic analysis of GWAS data.

The paper examines DNA hypermethylation in developmental contexts, identifying gene-specific methylation patterns and their links to transcriptional regulation in human cell types.