MicrobiologybioRxivPreprint
A Novel COE-D8-Fosfomycin Conjugate Effectively Against First-line Antibiotic Resistant Uropathogenic Escherichia coli
Lin Ruan, Cun Fan, Jingjie Chen…·Chunming Guo
This paper evaluates a novel conjugate, COE-D8, against antibiotic-resistant UPEC, showing reduced resistance and faster bacterial elimination, but with cytotoxicity mitigated by combination with fosfomycin.
DOI 10.1101/2025.01.19.633753