Author

Chunming Guo

Yunnan UniversityORCID 0009-0007-6141-0037Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:bacteria (other)· 1 Research Focus:benchmarking· 1 Organism:E. coli· 1 Approach:machine learning (classical)· 1 Approach:statistical model· 1

Frequent Co-Authors

Cun Fan· 2 shared Jingjie CheniD· 2 shared Yingying PuiD· 2 shared Yuji Ren· 2 shared Chenyi WangiD· 1 shared Chun Huang· 1 shared Fang CheniD· 1 shared Haifeng Wang· 1 shared

Activity by Year

2024-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersMicrobiology

Cun Fan

Mutual co-authors in cluster

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3 papers

Recent·Most cited

MicrobiologybioRxivPreprintJan 19, 2025

A Novel COE-D8-Fosfomycin Conjugate Effectively Against First-line Antibiotic Resistant Uropathogenic Escherichia coli

Lin Ruan, Cun Fan, Jingjie Chen…·Chunming Guo

This paper evaluates a novel conjugate, COE-D8, against antibiotic-resistant UPEC, showing reduced resistance and faster bacterial elimination, but with cytotoxicity mitigated by combination with fosfomycin.

DOI 10.1101/2025.01.19.633753

E. coliexperimental assay

𝕏 PostBluesky

MicrobiologyeLifePeer-reviewedAug 6, 2024

Cyclic di-GMP as an Antitoxin Regulates Bacterial Genome Stability and Antibiotic Persistence in Biofilms

Hebin Liao, Xiaodan Yan, Chenyi Wang…·Yingying Pu

The paper identifies a toxin-antitoxin system in biofilms where c-di-GMP regulates genome stability and antibiotic persistence by controlling HipH activity.

13 citations

experimental assayhost-pathogen & immune response

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BioinformaticsbioRxivPreprintJun 12, 2024

Intra-genomic genes-to-genes correlation enables genome representation

Jingjie Chen, Xuchuan Ma, Junwei He…·Chunming Guo

The paper shows that combinations of highly variable core genes can accurately predict sequence variants and antibiotic resistance in bacterial genomes.

1 citation

bacteria (other)whole-genome sequencing

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