Pia Laitinen

This study examines miRNA distribution and function in nuclear and cytoplasmic compartments of human endothelial cells under hypoxia, revealing nuclear-specific roles in cell proliferation and inflammation.

The paper evaluates isomiR expression differences across conditions and shows their impact on miRNA-seq quantification, highlighting the need for isomiR-aware analysis.

The paper shows isomiRs significantly affect differential expression analysis and highlights the need to consider them instead of relying solely on reference miRNA sequences.