Suvi Linna-Kuosmanen

This study identifies length-dependent hypercontractility as the initial phenotype of MYBPC3-haploinsufficiency in iPSC-derived cardiac tissues, decoupled from early transcriptional and metabolic changes.

This study shows that hepatic ketogenesis reduces cardiac hypertrophy in HFpEF by maintaining beta-hydroxybutyrate levels, which modulate myocardial metabolism.

The paper identifies metabolic human accelerated regions (mHARs) in adipose tissue that coordinate adaptive responses to nutrient deficit, revealing their role in maintaining metabolic homeostasis and resilience.

This study examines miRNA distribution and function in nuclear and cytoplasmic compartments of human endothelial cells under hypoxia, revealing nuclear-specific roles in cell proliferation and inflammation.

QClus improves snRNA-seq data quality by filtering droplets in challenging samples, achieving high quality across multiple datasets and metrics.

The paper uses single-nuclei RNA-seq and spatial transcriptomics to analyze gene expression changes in the right atrium of patients with ischemic heart disease, revealing inflammatory microvascular dysfunction and altered tissue composition.

The paper evaluates isomiR expression differences across conditions and shows their impact on miRNA-seq quantification, highlighting the need for isomiR-aware analysis.

The paper analyzes multi-omic data from two pig heart xenografts in human decedents to identify immune and metabolic responses associated with rejection and injury.

The paper shows isomiRs significantly affect differential expression analysis and highlights the need to consider them instead of relying solely on reference miRNA sequences.

The paper investigates how genome plasticity and transcriptional organization enable metabolic resilience to nutrient limitation and fasting endurance.