Pasi Tavi

This study identifies length-dependent hypercontractility as the initial phenotype of MYBPC3-haploinsufficiency in iPSC-derived cardiac tissues, decoupled from early transcriptional and metabolic changes.

QClus improves snRNA-seq data quality by filtering droplets in challenging samples, achieving high quality across multiple datasets and metrics.

The paper uses single-nuclei RNA-seq and spatial transcriptomics to analyze gene expression changes in the right atrium of patients with ischemic heart disease, revealing inflammatory microvascular dysfunction and altered tissue composition.

The paper evaluates isomiR expression differences across conditions and shows their impact on miRNA-seq quantification, highlighting the need for isomiR-aware analysis.