Eloi Schmauch

This study tracks T cell clonotypes across tissues in a pig-to-human kidney xenotransplantation model, showing coordinated immune responses preceding xenograft rejection.

This study identifies length-dependent hypercontractility as the initial phenotype of MYBPC3-haploinsufficiency in iPSC-derived cardiac tissues, decoupled from early transcriptional and metabolic changes.

This study examines miRNA distribution and function in nuclear and cytoplasmic compartments of human endothelial cells under hypoxia, revealing nuclear-specific roles in cell proliferation and inflammation.

QClus improves snRNA-seq data quality by filtering droplets in challenging samples, achieving high quality across multiple datasets and metrics.

The paper uses single-nuclei RNA-seq and spatial transcriptomics to analyze gene expression changes in the right atrium of patients with ischemic heart disease, revealing inflammatory microvascular dysfunction and altered tissue composition.

The paper evaluates isomiR expression differences across conditions and shows their impact on miRNA-seq quantification, highlighting the need for isomiR-aware analysis.

The paper analyzes multi-omic data from two pig heart xenografts in human decedents to identify immune and metabolic responses associated with rejection and injury.

The paper identifies that DNA double strand breaks in neurons activate immune pathways, leading to microglia activation in neurodegeneration.

The paper shows isomiRs significantly affect differential expression analysis and highlights the need to consider them instead of relying solely on reference miRNA sequences.