A Rapidly Excretable, ROS-Scavenging Ionizable Lipid Decouples mRNA Delivery Potency from Toxicity
Yeji Lee, Han Jeong, Eunbin Kim, Y. C. Hwang, Yongjoo Byeon, Hyunsoo Kang, Min Seok Choi, Eun Hye Jeong, Jeong Hun Kwak, Min-Sung Kang, Ok-Hee Kim, Sairan Eom, J. Ahn, Yong Jin Lee, Suk Ho Byeon, , Hyukjin Lee
This paper introduces a dual-function ionizable lipid that reduces mRNA toxicity and enhances clearance, achieving high gene editing efficiency in a macular degeneration model.
bioRxiv · Apr 9, 2026 · PreprintBioengineering