Hyukjin Lee

This paper develops FATE, a mutation-agnostic base-editing platform that rescues HGPS phenotypes in neuromuscular organoids by disrupting the LMNA farnesylation motif.

This study shows that modifying ionizable lipids and formulation parameters of mRNA vaccines can enhance CD4+ T cell immunity and improve vaccine efficacy.

This paper introduces a dual-function ionizable lipid that reduces mRNA toxicity and enhances clearance, achieving high gene editing efficiency in a macular degeneration model.