Tianyang Mao

The paper develops a computational framework to minimize CD8⁺ T cell immunogenicity in designed proteins while preserving function, using a de novo luciferase as a model.

This paper improves mRNA vaccine efficacy by creating an inflammatory immune niche via injectable hydrogel depots that recruit immune cells and enhance humoral responses.

The paper identifies Th1 cells interacting with B cells at the T-B border in viral infections, suggesting they contribute to antibody production outside classical germinal centers.

SARS-CoV-2 5' UTR stem-loop 1 (SL1) lets reporters escape Nsp1 translational shutdown. LNA antisense oligos against SL1 restore Nsp1 suppression and reduce infected Vero E6 cells.

Respiratory-restricted SARS-CoV-2 infection in mice, without brain virus, drives white matter microglial reactivity, impaired neurogenesis, oligodendrocyte depletion and myelin loss lasting at least 7 weeks.

The paper introduces Multiscale PHATE, a method for exploring high-dimensional biomedical data, and applies it to identify immune cell signatures associated with severe COVID-19 outcomes.