NeurosciencebioRxivPreprint
Structure-function dissection of huntingtin exon 1 identifies a PRD-driven modifier of neuronal toxicity in Huntington's disease
Raffaele Iennaco, Camilla Maffezzini, Simone Maestri…·Elena F. Cattaneo
The paper identifies the proline-rich domain (PRD) of HTT exon 1 as a modifier of neuronal toxicity in Huntington's disease, showing that the human PRD exacerbates while the mouse PRD mitigates toxicity.