Author

Raffaele Iennaco

Istituto Nazionale Genetica MolecolareORCID 0000-0002-7309-7232Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:proteomics· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Elena F. CattaneoiD· 2 shared Alejandro ToboniD· 1 shared Alessio MurgiaiD· 1 shared Andrea FalquiiD· 1 shared Andrea ScolziD· 1 shared Angela BachiiD· 1 shared Angela Cattaneo· 1 shared Berta Marcó de la CruziD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersNeuroscience

Elena F. CattaneoORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Structure-function dissection of huntingtin exon 1 identifies a PRD-driven modifier of neuronal toxicity in Huntington's disease

Raffaele Iennaco, Camilla Maffezzini, Simone Maestri, Andrea Scolz, Angela Cattaneo, Alessio Murgia, Camilla Trovesi, Eugenia Cammarota, Elena Vezzoli, Andrea Falqui, Dan P. Felsenfeld, Thomas Vogt, Angela Bachi, Chiara Zuccato, Elena F. Cattaneo

The paper identifies the proline-rich domain (PRD) of HTT exon 1 as a modifier of neuronal toxicity in Huntington's disease, showing that the human PRD exacerbates while the mouse PRD mitigates toxicity.

bioRxiv · Jul 27, 2026 · PreprintNeuroscience

Human cortical organoids expose a differential function of GSK3 on direct and indirect neurogenesis

Alejandro Tobon, Carlo Emanuele Villa, Cristina Cheroni, Sebastiano Trattaro, Nicolò Caporale, Paola Conforti, Raffaele Iennaco, Maria Lachgar-Ruiz, Marco Tullio Rigoli, Berta Marcó de la Cruz, Pietro Lo Riso, Erika Tenderini, Flavia Troglio, Marco de Simone, Isabel Liste, , Giuseppe Testa

This study uses human cortical organoids to show that GSK3 inhibition affects progenitor proliferation and tissue architecture, with specific impacts on outer radial glia and astrogenic lineage.

bioRxiv · Mar 4, 2019 · PreprintDevelopmental Biology