Cancer BiologybioRxivPreprint
Hypoxia drives trastuzumab resistance through Rac1 pathway in HER2-positive breast cancer
Virginia Judith Wolos, Giulia Rocca, Marianela Abrigo…·Gabriel L. Fiszman
This study identifies hypoxia-driven Rac1 pathway activation as a mechanism of trastuzumab resistance in HER2-positive breast cancer and shows Rac1 inhibition can restore drug sensitivity.
DOI 10.64898/2026.05.05.723085