Ezequiel Lacunza

This paper identifies how KSHV alters mesenchymal cell glycosylation to enhance PDGFRA signaling, contributing to Kaposi sarcoma pathogenesis.

This paper shows that KSHV-infected cells can form tumors in immunocompetent mice when pretreated with EcoHIV and morphine, mimicking human KS lesions.

This study identifies hypoxia-driven Rac1 pathway activation as a mechanism of trastuzumab resistance in HER2-positive breast cancer and shows Rac1 inhibition can restore drug sensitivity.

This study identifies SPARC as a driver of early breast tumor progression through a TGF-β-dependent mechanism, showing its correlation with MT1-MMP and invasiveness.

This study shows that OSKM gene therapy in old rats improves spatial learning and memory, reduces epigenetic age, and reverses age-related DNA methylation changes in the hippocampus.

This study shows that young rat plasma reduces DNA methylation age, extends lifespan, and improves health in old rats.