Giorgio Arrigoni

LRRK2 regulates synaptic function through modulation of actin cytoskeletal dynamics

This study shows that LRRK2 regulates synaptic function by modulating actin cytoskeletal dynamics through BDNF signaling in neurons.

Loss of catalytic activity and impaired proteostasis in guanosine nucleotide-depleted LRRK2

This study investigates the functional consequences of catalytic activity loss in LRRK2, showing impaired proteostasis and altered interactome in guanosine nucleotide-depleted Lrrk2.

Hypoxia drives trastuzumab resistance through Rac1 pathway in HER2-positive breast cancer

This study identifies hypoxia-driven Rac1 pathway activation as a mechanism of trastuzumab resistance in HER2-positive breast cancer and shows Rac1 inhibition can restore drug sensitivity.

COA8 is a COX10-binding protein involved in the early biogenesis of cytochrome c oxidase

This study identifies COA8 as a COX10-binding protein essential for COX10 stability and catalytic activity in human cytochrome c oxidase biogenesis.

Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinson's disease

This study shows that the LRRK2 G2019S mutation impairs EAAT2 trafficking, leading to reduced glutamate clearance and potential neurodegeneration in Parkinson's disease.