Author

Niels Keijzer

The Netherlands Cancer InstituteORCID 0009-0008-1038-6281Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1

Frequent Co-Authors

Alexander FishiD· 1 shared Farid El OualidiD· 1 shared Jan SakoltchikiD· 1 shared Kaustav MajumderiD· 1 shared Nina van LiliD· 1 shared Titia K. SixmaiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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6 top collaborators · 15 mutual co-author links

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1 shared paperBiochemistry

Alexander FishORCID

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1 paper

Recent·Most cited

BiochemistryNature CommunicationsPeer-reviewedJul 30, 2025

USP1/UAF1 targets polyubiquitinated PCNA with an exo-cleavage mechanism that enriches for monoubiquitinated PCNA

Niels Keijzer, Jan Sakoltchik, Kaustav Majumder…·Titia K. Sixma

This study shows USP1/UAF1 cleaves K48 and K63-linked ubiquitin chains on PCNA via exo-cleavage, preferentially enriching monoubiquitinated PCNA, which may influence DNA damage tolerance pathway choice.

14 citationstop 5%

experimental assaychromatin & epigenetic regulation

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