Author

Lukas Deweid

Novo Nordisk (Denmark)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Approach:statistical model· 1

Frequent Co-Authors

Amir MotmaeniD· 1 shared Amrita Nallathambi· 1 shared Ana-Maria BratovianuiD· 1 shared André LieberiD· 1 shared Andreas HaldiD· 1 shared Anja Bennett· 1 shared Annu Dalal· 1 shared Arun K. ShuklaiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperBioengineering

Amir MotmaenORCID

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2 papers

Recent·Most cited

pH-sensitive binder design with Proton-PottsMPNN

Christian P. Jacobsen, Lukas Deweid, Foster Birnbaum, Line W Gormsen, Thomas Fryer, Ulla Jagd, Andreas Hald, Morten Grønbech Rasch, Timothy P. Jenkins, Sergey Ovchinnikov

This paper introduces Proton-PottsMPNN, a model that designs pH-sensitive binders by explicitly modeling protonation states, resulting in pH-dependent PD-L1 binders with transition pH values between 4.0 and 5.8.

bioRxiv · Oct 1, 2026 · PreprintBiophysics

De novo design of miniprotein agonists and antagonists targeting G protein-coupled receptors

Edin Muratspahić, David Feldman, David E. Kim, Xiangli Qu, Ana-Maria Bratovianu, Paula Rivera-Sánchez, Jan Hendrik Voss, Emil Peter Thrane Hertz, Mads Jeppesen, Federica Dimitri, Kensuke Sakamoto, Amrita Nallathambi, Pia Peceli, Jianjun Cao, Brian P. Cary, , David A. Baker

This paper presents computational methods for designing GPCR-binding miniproteins and validates them through high-throughput screening, producing agonists and antagonists for multiple GPCRs.

bioRxiv · Mar 23, 2025 · PreprintBioengineering