Stephen C. Wilson

This study uses deep mutational scanning to analyze TYK2 variants and their impact on function and drug response, identifying novel therapeutic targets and degradation strategies.

This study identifies CK2 as a regulator of CARD9 protein stability, showing CK2 inhibition leads to CARD9 depletion and demonstrating therapeutic potential in vivo.

This study identifies a critical residue for STING activation and shows how an orthosteric inhibitor can partially correct a SAVI mutation.