Xiaoyong Li

The paper identifies the Zld interactome in Drosophila embryos, revealing co-factors essential for ZGA, including dCBP, Fsh, and Smr, and shows RNAPII associates with Zld-bound enhancers.

The paper investigates Zelda's role in zygotic enhancer activity in Drosophila embryos, finding that most enhancers show limited effects from Zelda site mutations, while one loses activity entirely, and that chromatin environment influences Zelda's effect.

The paper shows that mutating sequences around Bicoid binding sites in a Drosophila enhancer has a greater impact on its activity than mutating the Bicoid sites themselves.

The paper investigates Zelda's role in early Drosophila embryogenesis, showing it enhances chromatin accessibility and coordinates enhancer activity with maternal factors.

The paper uses live imaging in Drosophila embryos to show that Bicoid binds DNA with a rapid off-rate and forms localized hubs that enable concentration-sensitive regulation.