PhysiologybioRxivPreprint
Salt-inducible kinase inhibition promotes weight loss and improves the diastolic function of obesity-related heart failure with preserved ejection fraction in mice
Fubiao Shi, Vineet Agrawal, Uugantsetseg Munkhjargal…·Sheila Collins
This study shows that inhibiting salt-inducible kinases (SIKs) reduces weight gain and improves diastolic heart function in obese mice with heart failure with preserved ejection fraction (HFpEF).
DOI 10.1101/2025.03.02.640935