An increased excitation and inhibition onto CA1 pyramidal cells sets the path to Alzheimer's disease
Patrick H. Wehrle, Travis J. Rathwell, Maurice A. Petroccione, Ethan D. Caiazza, Anthony K. Manning, Leonardo Frasson dos Reis, Gabrielle C. Todd, Nurat Affinnih, Saad Ahmad, Hasan Mehdi, Ian L. Tschang, Umair Hassan, Brianna R. Tsakh, Marisol C. Lauffer, Paul A. Rosenberg, , Annalisa Scimemi
This study shows that Aβ42 accumulation increases excitatory and inhibitory synaptic transmission onto CA1 pyramidal cells and GLT-1 expression, which mediates its effects on cognition.
bioRxiv · May 27, 2025 · PreprintNeuroscience