Citu Citu

This study uses single-nucleus RNA-sequencing and multiome data to identify neuronal mitochondrial gene suppression as a driver of Alzheimer's dementia, revealing genetic and epigenetic mechanisms underlying cognitive resilience.

This study shows that ERRγ activation in aged mice reduces sarcopenia by enhancing mitochondrial function, vascularization, and neuromuscular junctions while preserving exercise capacity.

This study creates a single-nucleus multiome atlas of sEOAD brain regions, identifying key transcription factors and regulatory elements linked to disease.

This study shows that ERRα promotes skeletal muscle regeneration and reduces dystrophy in DMD by enhancing angiogenesis and mitochondrial function.

This study identifies 268 new viral transcriptional regulators (vTRs) from 14 families, maps their binding sites, and links them to immune-mediated diseases and cancers, suggesting therapeutic targets.