Nitesh Enduru

Single-Nucleus Profiling Reveals Neuronal Metabolic Collapse During the Transition to Alzheimer's Disease Dementia

This study uses single-nucleus RNA-sequencing and multiome data to identify neuronal mitochondrial gene suppression as a driver of Alzheimer's dementia, revealing genetic and epigenetic mechanisms underlying cognitive resilience.

Single-nucleus multiomics reveals the disrupted regulatory programs in three brain regions of sporadic early-onset Alzheimer's disease

This study creates a single-nucleus multiome atlas of sEOAD brain regions, identifying key transcription factors and regulatory elements linked to disease.

Identification and catalogue of viral transcriptional regulators in human diseases

This study identifies 268 new viral transcriptional regulators (vTRs) from 14 families, maps their binding sites, and links them to immune-mediated diseases and cancers, suggesting therapeutic targets.