Astrid Marilyn Manuel

Tractor-Burden improves gene discovery in admixed populations by incorporating local ancestry in rare variant burden testing, identifying additional genes and pathways for type 2 diabetes.

This study creates a single-nucleus multiome atlas of sEOAD brain regions, identifying key transcription factors and regulatory elements linked to disease.

This study identifies 268 new viral transcriptional regulators (vTRs) from 14 families, maps their binding sites, and links them to immune-mediated diseases and cancers, suggesting therapeutic targets.

This paper constructs a single-cell atlas of Alzheimer's disease brain tissue and identifies drug repositioning candidates by analyzing cellular heterogeneity and gene expression patterns.

The paper estimates population-specific and shared causal SNPs from GWAS summary data across East Asian and European populations and finds shared SNPs are enriched in functional categories.