Li J

This study identifies APOH as a promoter of aortic dissection by activating the NR5A1-PPARγ pathway in vascular smooth muscle cells, leading to phenotypic switching and inflammation.

The paper identifies VinBLAST, a scaffold protein that facilitates the biosynthesis of monoterpenoid indole alkaloids by enhancing the interaction and activity of key enzymes.

This paper introduces SpaWeaver, a framework for robust spatial multi-omics integration using weak anchors, showing improved performance in handling real-world challenges and enabling new biological insights.

The paper uses long-read RNA-seq to uncover isoform-level and context-specific regulatory effects in cattle, improving the resolution of molecular atlases and GWAS loci.

This paper designs an engineered PET hydrolase, VenusPETase, using deep learning to enhance PET depolymerization efficiency and thermostability, achieving high TPA yields and complete degradation of commercial PET.