Yong Yu

Discovery of SMCs that correct MAPT splicing, reduce 4R tau, and rescue pathology in patient-derived neuronal and in vivo models of 4R tauopathies.

The paper uses deep learning to identify new gene targets for a splicing modulator drug, validating predictions with in vitro assays.

The paper identifies distinct phases of axon degeneration regulated by p75NTR and DR6, showing calcium flux and spheroid rupture as key events.