Pharmacology & ToxicologybioRxivPreprint
Binding to Albumin and Off-Target Toxicity Confound the Use of LRRC8/VRAC Channel Blockers in Cell Physiology Assays
Marianne Touma Boulos, Aayan M. Afghan, Alena Rudkouskaya…·Alexander A. Mongin
This study shows that VRAC blockers have off-target effects and cytotoxicity masked by serum albumin, suggesting they are not reliable for studying VRAC function.
DOI 10.64898/2026.07.13.737859