Alexander A. Mongin

This study identifies LRRC8A/D-containing VRACs as the main pathway for swelling-activated taurine release in the brain but shows this pathway is not essential for systemic osmoregulation.

This study shows that VRAC blockers have off-target effects and cytotoxicity masked by serum albumin, suggesting they are not reliable for studying VRAC function.

The paper investigates the subunit composition and functional roles of LRRC8 proteins in determining glutamate permeability of astrocytic VRACs using genetic and molecular approaches.

This study identifies LRRC8A-containing anion channels as promoters of glioblastoma proliferation through a WNK1/mTORC2-dependent mechanism.

This study shows that Gα12 and Gα13 proteins are essential for TGF-β-induced myofibroblast differentiation by regulating Smad phosphorylation and receptor expression.

This study shows that deleting LRRC8A in the brain reduces stroke damage without affecting glutamate release, challenging the idea that VRACs contribute to stroke via glutamate release.

This study shows that brain-specific deletion of LRRC8A in mice leads to early mortality due to seizures, astrogliosis, and amino acid neurotransmitter dysregulation.