Ariel Madrigal

This study identifies TCF4 as a downstream effector of PHF6 in neural stem cell regulation, showing its role in restricting self-renewal and rescuing BFLS phenotypes.

This study identifies LOX as a driver of ccRCC progression by sustaining HIF-2α transcription and modulating the tumor microenvironment.

This study identifies 59 gene expression programs in RCC that reveal subtype identity and metastatic trajectories, including a metastatic signature linked to poor clinical outcomes.

The paper identifies intra-genic mutational robustness through alternative splicing in cancer, showing it can complement inter-genic robustness and is associated with worse disease outcomes.

This paper introduces scLSD, a thermodynamics-inspired model for cell differentiation that reconstructs differentiation trajectories and predicts fate commitment, outperforming existing methods.

This paper introduces GEDI, a generative model that unifies multi-sample, multi-condition single-cell analysis tasks, enabling cross-sample cell state mapping, differential gene expression, and pathway activity projection.