Özge Saatci

TACC3-driven translation reprogramming dictates susceptibility or tolerance to mitotic stress

This study identifies TACC3 as a coordinator of translation and epitranscriptomic reprogramming that determines cancer cell sensitivity or tolerance to mitotic stress induced by microtubule targeting agents.

Lysyl oxidase drives ccRCC progression by coordinating HIF-2α transcription program with tumor microenvironment

This study identifies LOX as a driver of ccRCC progression by sustaining HIF-2α transcription and modulating the tumor microenvironment.

Single-cell gene programs define subtype identity and metastatic trajectories in renal cell carcinoma

This study identifies 59 gene expression programs in RCC that reveal subtype identity and metastatic trajectories, including a metastatic signature linked to poor clinical outcomes.

Single-Cell Microwave Cytometry for Drug Resistance Detection in Cancer

This paper introduces a single-cell electronic cytometry platform using microwave resonators to detect drug resistance in cancer by measuring biophysical properties, showing its effectiveness in cancer cell lines and patient-derived organoids.