Nicholas Thomas Perry

Prokaryotic homologs of the major vault protein form engineerable vault nanocapsules

The paper identifies prokaryotic homologs of the major vault protein that assemble into vault nanocapsules, revealing structural and size variability.

Autonomous AI agents discover reverse transcriptases with tandem repeat arrays

The paper uses large language models to discover a novel family of reverse transcriptases with tandem repeat arrays from metagenomic data.

Megabase-scale human genome rearrangement with programmable bridge recombinases

This paper describes the engineering of IS622 bridge recombinases to enable efficient and specific DNA rearrangements in the human genome, including insertion, inversion, and excision of up to 0.93 megabases.

Bridge RNAs direct modular and programmable recombination of target and donor DNA

The paper demonstrates that IS110 insertion sequences use a structured RNA to direct sequence-specific DNA recombination, enabling modular genome editing.

Multi-input drug-controlled switches of mammalian gene expression based on engineered nuclear hormone receptors

The paper demonstrates multi-input drug-controlled gene expression using engineered nuclear hormone receptors, showing tunable outputs with multiple drugs.