Author

Johanna K. Freundt

University of MünsterORCID 0009-0009-1356-7624Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:imaging· 1 Organism:mouse· 1 Assay:structural biology· 1

Frequent Co-Authors

Wolfgang Albrecht LinkeiD· 2 shared Andreas Unger· 1 shared Anne HelfeniD· 1 shared Annika J. Klotz· 1 shared Anthony L. HesseliD· 1 shared Christine M. LoescheriD· 1 shared Cornelius FaberiD· 1 shared Devin L. NisseniD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersPhysiology

Wolfgang Albrecht LinkeORCID

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2 papers

Recent·Most cited

PhysiologyPhysiological ReportsPeer-reviewedOct 1, 2025

Mavacamten facilitates myosin head ON-to-OFF transitions and shortens thin filament length in relaxed skeletal muscle

Michel N. Kuehn, Nichlas M. Engels, Devin L. Nissen…·Anthony L. Hessel

This study examines how mavacamten affects skeletal muscle structure by reducing ON-state myosin heads and shortening thin filament length, similar to its effects in cardiac muscle.

4 citations

structural biologyexperimental assay

𝕏 PostBluesky

PhysiologybioRxivPreprintApr 21, 2025

Titin cleavage impairs cardiac mechanical connectivity to drive diastolic failure and fibrosis

Johanna K. Freundt, Paulina Hartmann, Christine M. Loescher…·Wolfgang Albrecht Linke

This study shows that titin cleavage in mice causes concentric cardiac remodeling, diastolic dysfunction, and fibrosis by disrupting mechanical connectivity.

1 citation

mouseimaging

𝕏 PostBluesky