Titin cleavage impairs cardiac mechanical connectivity to drive diastolic failure and fibrosis
Johanna K. Freundt, Paulina Hartmann, Christine M. Loescher, Andreas Unger, Franziska Koser, Annika J. Klotz, Lydia Wachsmuth, Susanne S. Hille, Michaela M. Door, Anne Helfen, Richard Holtmeier, Cornelius Faber, Jonathan A. Kirk, Verena Hoerr, Oliver J Mueller, Wolfgang Albrecht Linke
This study shows that titin cleavage in mice causes concentric cardiac remodeling, diastolic dysfunction, and fibrosis by disrupting mechanical connectivity.
bioRxiv · Apr 21, 2025 · PreprintPhysiology