NeurosciencebioRxivPreprint
WNK-SPAK/OSR1 signaling pathway facilitates ictal activity via reduced neuronal chloride extrusion rate
Volodymyr I. Dzhala, Fu Hung Shiu, Negah Rahmati…·Kevin J. Staley
This study shows that inhibiting the WNK-SPAK/OSR1 pathway reduces neuronal chloride intracellular levels and suppresses ictal-like discharges by enhancing chloride extrusion through NKCC1 and KCC2.
DOI 10.64898/2026.06.10.731153