Kevin J. Staley

This study shows that acute ClC-2 inhibition depolarizes EGABA, increases neuronal intracellular chloride, and alters GABAergic chloride signaling dynamics.

This study evaluates synthetic kainic acid injection parameters in the IHK model to reliably induce seizures while minimizing mortality.

This study shows that inhibiting the WNK-SPAK/OSR1 pathway reduces neuronal chloride intracellular levels and suppresses ictal-like discharges by enhancing chloride extrusion through NKCC1 and KCC2.

This study examines seizure patterns in a porcine model of post-traumatic epilepsy, finding that seizures start focally and evolve to generalized convulsions with stereotypical behaviors.

This study measures sulfated glycosaminoglycan (sGAG) levels in ventricular CSF, blood, and urine of TBI patients to assess extracellular matrix damage and its correlation with injury characteristics.

This study shows that mild perinatal hypoxia-ischemia causes delayed and prolonged neuronal death, with neurons dying later showing normal function and viability for days post-injury.

The paper measures extracellular chloride concentrations in the brain and finds they are lower and more variable than previously thought due to displacement by immobile anions, affecting GABAA receptor function.

The paper investigates how brief apnea and hypoventilation (A&H) after seizures in a severe TBI model reduces seizure duration and shifts seizure location for several hours.

This study identifies the cellular sources of ictal population signals in seizures using calcium imaging and electrophysiology in mouse models.

This paper develops techniques for high-resolution 2-photon imaging of fluorescent proteins in living swine brains, addressing challenges in motion artifact and large animal imaging.

The paper shows that after acute brain injury, microglial phagocytosis becomes overwhelmed, leading to a buildup of dying neurons and highlighting the need for longitudinal assays to accurately measure cell death.

This paper describes a long-term video EEG monitoring system in a porcine model of post-traumatic epilepsy, demonstrating its utility for studying epileptogenesis over 14 months.

The paper measures chloride ion concentrations in neurons to show the existence of stable cytoplasmic chloride microdomains that affect GABAergic signaling.