Fu Hung Shiu

This study shows that acute ClC-2 inhibition depolarizes EGABA, increases neuronal intracellular chloride, and alters GABAergic chloride signaling dynamics.

This study shows that inhibiting the WNK-SPAK/OSR1 pathway reduces neuronal chloride intracellular levels and suppresses ictal-like discharges by enhancing chloride extrusion through NKCC1 and KCC2.

The paper measures extracellular chloride concentrations in the brain and finds they are lower and more variable than previously thought due to displacement by immobile anions, affecting GABAA receptor function.