Author

Volodymyr I. Dzhala

Harvard UniversityORCID 0009-0001-2875-4352Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:electronic health records· 2 Organism:mouse· 2 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Assay:imaging· 1 Approach:statistical model· 1

Frequent Co-Authors

Kevin J. StaleyiD· 4 shared Kyle P. LillisiD· 3 shared Negah RahmatiiD· 3 shared Fu Hung ShiuiD· 2 shared Kristopher Thomas KahleiD· 2 shared Aloe CarrolliD· 1 shared Eugene Berdichevsky· 1 shared Fatemeh BahariiD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersNeuroscience

Kevin J. StaleyORCID

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4 papers

Recent·Most cited

Acute ClC-2 blockade increases neuronal intracellular chloride and depolarizes EGABA

Fu Hung Shiu, Volodymyr I. Dzhala, Kyle P. Lillis, Kevin J. Staley

This study shows that acute ClC-2 inhibition depolarizes EGABA, increases neuronal intracellular chloride, and alters GABAergic chloride signaling dynamics.

bioRxiv · Sep 30, 2026 · PreprintNeuroscience

WNK-SPAK/OSR1 signaling pathway facilitates ictal activity via reduced neuronal chloride extrusion rate

Volodymyr I. Dzhala, Fu Hung Shiu, Negah Rahmati, Aloe Carroll, Reagan Bae, Kristopher Thomas Kahle, Kevin J. Staley

This study shows that inhibiting the WNK-SPAK/OSR1 pathway reduces neuronal chloride intracellular levels and suppresses ictal-like discharges by enhancing chloride extrusion through NKCC1 and KCC2.

bioRxiv · Sep 14, 2026 · PreprintNeuroscience

A dynamic balance between neuronal death and clearance after acute brain injury

Trevor Balena, Kyle P. Lillis, Negah Rahmati, Fatemeh Bahari, Volodymyr I. Dzhala, Eugene Berdichevsky, Kevin J. Staley

The paper shows that after acute brain injury, microglial phagocytosis becomes overwhelmed, leading to a buildup of dying neurons and highlighting the need for longitudinal assays to accurately measure cell death.

bioRxiv · Feb 14, 2023 · PreprintNeuroscience

Unique actions of GABA arising from cytoplasmic chloride microdomains

Negah Rahmati, Kieran P. Normoyle, Joseph C. Glykys, Volodymyr I. Dzhala, Kyle P. Lillis, Kristopher Thomas Kahle, Rehan Raiyyani, Theju Jacob, Kevin J. Staley

The paper measures chloride ion concentrations in neurons to show the existence of stable cytoplasmic chloride microdomains that affect GABAergic signaling.

Journal of Neuroscience · Apr 26, 2021Peer-reviewedNeuroscience