Author

Aria Zheyuan Huang

University of PennsylvaniaORCID 0009-0009-3042-3171Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 2 Developmental Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:clustering· 3 Research Focus:cell-cell communication· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Alex J. HughesiD· 4 shared Louis S. PrahliD· 3 shared Samuel H. GrindeliD· 2 shared Amin AbediniiD· 1 shared Andi M. Bergeson· 1 shared Bernhard DumouliniD· 1 shared Boaz Weicz· 1 shared Daniel Alber· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersBioengineering

Alex J. HughesORCID

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4 papers

Recent·Most cited

BioengineeringbioRxivPreprintApr 2, 2026

Synthetic budding morphogenesis by optogenetic receptor tyrosine kinase signaling

Louis S. Prahl, Ronald Canlla, Aria Zheyuan Huang…·Alex J. Hughes

This paper uses optogenetic control of RET signaling to induce controlled budding in human kidney organoids.

DOI 10.64898/2026.03.31.715459

𝕏 PostBluesky

Developmental BiologyNature CommunicationsPeer-reviewedAug 22, 2025

Engineering kidney developmental trajectory using culture boundary conditions

Aria Zheyuan Huang, Louis S. Prahl, Karen L. Xu…·Alex J. Hughes

This paper develops a 3D culture technique to study kidney development and shows that matrix stiffness and adhesion influence nephron formation and spacing.

3 citations

experimental assay

𝕏 PostBluesky

GenomicsbioRxivPreprintJun 15, 2025

Single-Cell Spatial Mapping of Human Kidney Development Reveals the Critical Role of the Local Microenvironment in Cell Fate Decisions

Jonathan L. Levinsohn, Samuel H. Grindel, Bernhard Dumoulin…·Katalin Suszták

The paper maps human kidney development using single-cell RNA sequencing and spatial transcriptomics, revealing fate decisions influenced by the local microenvironment.

DOI 10.1101/2025.06.15.659579

𝕏 PostBluesky

BioengineeringProceedings of the National Academy of SciencesPeer-reviewedSep 18, 2024

Measurement of adhesion and traction of cells at high yield (MATCHY) reveals an energetic ratchet driving nephron condensation

Jiageng Liu, Louis S. Prahl, Aria Zheyuan Huang, Alex J. Hughes

MATCHY quantifies cell adhesion and traction in primary kidney cells, revealing an energetic ratchet mechanism driving nephron condensation during differentiation.

3 citations

𝕏 PostBluesky