Author

Louis S. Prahl

University of PennsylvaniaORCID 0000-0002-7811-6041Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 2 Developmental Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:clustering· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1

Frequent Co-Authors

Alex J. HughesiD· 4 shared Aria Zheyuan HuangiD· 2 shared Jiageng Liu· 2 shared Aria Huang· 1 shared Daniel Alber· 1 shared Jason A. BurdickiD· 1 shared John M. Viola· 1 shared Karen L. XuiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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4 shared papersBioengineering

Alex J. HughesORCID

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Author profile →

4 papers

Recent·Most cited

Synthetic budding morphogenesis by optogenetic receptor tyrosine kinase signaling

Louis S. Prahl, Ronald Canlla, Aria Zheyuan Huang, Daniel Alber, Sandra L. Shefter, Sachin Davis, Samuel H. Grindel, Zikang Dennis Huang, Thomas R. Mumford, William K. J. Benman, Lukasz J. Bugaj, Kyle W. McCracken, Alex J. Hughes

This paper uses optogenetic control of RET signaling to induce controlled budding in human kidney organoids.

bioRxiv · Apr 2, 2026 · PreprintBioengineering

Engineering kidney developmental trajectory using culture boundary conditions

Aria Zheyuan Huang, Louis S. Prahl, Karen L. Xu, Robert L. Mauck, Jason A. Burdick, Alex J. Hughes

This paper develops a 3D culture technique to study kidney development and shows that matrix stiffness and adhesion influence nephron formation and spacing.

Nature Communications · Aug 22, 2025Peer-reviewedDevelopmental Biology

Measurement of adhesion and traction of cells at high yield (MATCHY) reveals an energetic ratchet driving nephron condensation

Jiageng Liu, Louis S. Prahl, Aria Huang, Alex J. Hughes

MATCHY quantifies cell adhesion and traction in primary kidney cells, revealing an energetic ratchet mechanism driving nephron condensation during differentiation.

bioRxiv · Feb 7, 2024 · PreprintBioengineering

The developing kidney actively negotiates geometric packing conflicts to avoid defects

Louis S. Prahl, John M. Viola, Jiageng Liu, Alex J. Hughes

The paper shows how mouse embryonic kidney epithelium resolves geometric packing conflicts through internally generated tensions to avoid defects.

Developmental Cell · Jan 1, 2023Peer-reviewedDevelopmental Biology