The paper identifies splicing variants in human kidney tissue associated with kidney function and cardiovascular-kidney-metabolic syndrome traits using long-read RNA sequencing and QTL analysis.

medRxiv · Oct 2, 2025 · PreprintGenetic & Genomic Medicine

Single-Cell Spatial Mapping of Human Kidney Development Reveals the Critical Role of the Local Microenvironment in Cell Fate Decisions

Jonathan L. Levinsohn, Samuel H. Grindel, Bernhard Dumoulin, Amin Abedini, Aria Zheyuan Huang, Rena Levin-Klein, Boaz Weicz, Grace Rabinowitz, Andi M. Bergeson, Eunji Ha, Konstantin A. Klötzer, Nancy Ruonan Zhang, Paul M. Titchenell, Mingyao Li, Joo‐Seop Park, , Katalin Suszták

The paper maps human kidney development using single-cell RNA sequencing and spatial transcriptomics, revealing fate decisions influenced by the local microenvironment.

bioRxiv · Jun 15, 2025 · PreprintGenomics

Genetic Studies Highlight the Role of TET2 and INO80 in DNA Damage Response and Kidney Disease Pathogenesis

Xiujie Liang, Hongbo Liu, Hailong Hu, Jianfu Zhou, Amin Abedini, Andrea Navarro, Konstantin A. Klötzer, Katalin Suszták

This study identifies TET2 and INO80 as key genes in kidney disease pathogenesis through GWAS, single-cell analysis, and mouse models, showing their role in DNA damage response and disease progression.

bioRxiv · Feb 2, 2024 · PreprintGenetics

Spatially resolved human kidney multi-omics single cell atlas highlights the key role of the fibrotic microenvironment in kidney disease progression

Amin Abedini, Jonathan L. Levinsohn, Konstantin A. Klötzer, Bernhard Dumoulin, Ziyuan Ma, Julia Frederick, Poonam Dhillon, Michael S. Balzer, Rojesh Shrestha, Hongbo Liu, Steven Vitale, Kishor B. Devalaraja-Narashimha, Paola Grandi, Tanmoy Bhattacharyya, Erding Hu, , Katalin Suszták

Multi-omic and spatial profiling of 81 human kidney samples resolves four tissue microenvironments; the fibrotic one's gene signature is reported to beat histopathology at predicting outcome.

bioRxiv · Oct 24, 2022 · PreprintGenetics