Author

Samuel H. Grindel

University of PennsylvaniaORCID 0000-0001-8280-312XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Bioengineering· 1 Developmental Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:clustering· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Approach:experimental assay· 2 Organism:mouse· 2 Assay:spatial transcriptomics· 2 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Alex J. HughesiD· 3 shared Aria Zheyuan HuangiD· 2 shared Kotaro SasakiiD· 2 shared Sachin Davis· 2 shared Amin AbediniiD· 1 shared Andi M. Bergeson· 1 shared Andrew P. McMahoniD· 1 shared Aria Huang· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersBioengineering

Alex J. HughesORCID

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3 papers

Recent·Most cited

BioengineeringbioRxivPreprintApr 2, 2026

Synthetic budding morphogenesis by optogenetic receptor tyrosine kinase signaling

Louis S. Prahl, Ronald Canlla, Aria Zheyuan Huang…·Alex J. Hughes

This paper uses optogenetic control of RET signaling to induce controlled budding in human kidney organoids.

DOI 10.64898/2026.03.31.715459

𝕏 PostBluesky

GenomicsbioRxivPreprintJun 15, 2025

Single-Cell Spatial Mapping of Human Kidney Development Reveals the Critical Role of the Local Microenvironment in Cell Fate Decisions

Jonathan L. Levinsohn, Samuel H. Grindel, Bernhard Dumoulin…·Katalin Suszták

The paper maps human kidney development using single-cell RNA sequencing and spatial transcriptomics, revealing fate decisions influenced by the local microenvironment.

DOI 10.1101/2025.06.15.659579

𝕏 PostBluesky

Developmental BiologybioRxivPreprintNov 21, 2023

A mechanical pacemaker sets rhythmic nephron formation in the kidney

Samuel H. Grindel, Sachin Davis, Igor Guranovic…·Alex J. Hughes

This study identifies a mechanical pacemaker in the kidney stroma that synchronizes nephron formation with ureteric bud branching.

4 citations

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