Olivia Sun

This study identifies G3P-ChREBP as a mechanism linking Citrin Deficiency to metabolic dysfunction by activating FGF21 and lipogenesis, affecting food and alcohol choices.

The paper analyzes long-term cultured human islets to identify gene expression changes and cellular dynamics, revealing transdifferentiation and dedifferentiation processes.

The paper reassesses miRNA abundance in human pancreas and rodent cell lines, finding miR-148a-3p and miR-7-5p are equally abundant in islets, challenging the previous notion of miR-375-3p as the dominant miRNA.