J. Anthony Brandon

This study uses long-read single-cell sequencing to analyze isoform-level diversity in human PBMCs, identifying novel isoforms and cell-type-specific patterns.

The paper shows that a synonymous variant in PILRA decreases mRNA and protein levels by disrupting a ramp sequence, providing a biological mechanism for its association with Alzheimer's disease.

The paper uses long-read RNAseq to identify new RNA isoforms in Alzheimer's disease brain tissue and demonstrates their medical relevance.

This study surveys RNA isoform diversity and expression across nine GTEx tissues using long-read sequencing, revealing significant tissue-specific isoform variation and validating new isoforms.

This study identifies APOE4-associated metabolic changes in brain and systemic metabolism, showing increased aerobic glycolysis and reduced oxidative metabolism in both mice and humans.