Patricia Hayes Doyle

Beyond the gene: contextualizing novel isoforms through pathway analysis in long-read single-cell RNA sequencing

The paper develops a computational framework to contextualize novel isoforms identified through long-read single-cell RNA sequencing by integrating pathway analysis with expression-based neighborhoods.

Characterizing shared and distinctive molecular phenotypes across motor regions in ALS with and without TDP-43 pathology in a veteran cohort

The paper identifies senescence-associated molecular states in ALS motor neurons, showing regional and pathological differences but shared senescence features across ALS subtypes.

Decoding the human PBMC isonome: Isoform-level resolution with single-cell long-read transcriptomics

This study uses long-read single-cell sequencing to analyze isoform-level diversity in human PBMCs, identifying novel isoforms and cell-type-specific patterns.

Cognitive resilience to Alzheimers disease in mice depends on gene-diet interactions

This study identifies gene-diet interactions that influence cognitive resilience to Alzheimer's disease in mice, finding a diet-dependent genetic locus associated with resilience.

Using deep long-read RNAseq in Alzheimer's disease brain to assess medical relevance of RNA isoform diversity

The paper uses long-read RNAseq to identify new RNA isoforms in Alzheimer's disease brain tissue and demonstrates their medical relevance.