Molecular BiologybioRxivPreprint
A Naïve RNA Sampling Core Enables Adaptive piRNA Specificity Against Transposable Elements
Dominik Handler, W. WONG, Alexander Tsarev…·Julius Brennecke
The paper shows piRNA specificity arises from tissue-specific modules acting on non-specific RNA sampling, with Yb guiding processing in somatic cells and catalytic Argonaute triggering amplification in germline cells.