Dominik Handler

The paper identifies a noncanonical retrotransposon transmission mechanism in Drosophila that bypasses the need for viral envelope proteins.

The paper shows piRNA specificity arises from tissue-specific modules acting on non-specific RNA sampling, with Yb guiding processing in somatic cells and catalytic Argonaute triggering amplification in germline cells.

The paper shows that the Drosophila Piwi-piRNA pathway silences transposons by degrading their RNA via the nuclear exosome, with TEsup proteins facilitating this process.

The paper presents a high-quality genome assembly of Drosophila melanogaster ovarian somatic cells to study piRNA biology and transposon control.

The paper shows that antisense transposon insertions into host genes trigger piRNA-mediated immunity in Drosophila by generating chimeric transcripts that initiate silencing.

The paper identifies a conserved trimeric complex of Izumo1, Spaca6, and Tmem81 essential for sperm-egg interaction in vertebrates, showing their role in male fertility and binding to the egg protein Bouncer.

This study identifies an amino acid change in the HP1 protein Rhino that disrupts its interaction with Kipferl, altering chromatin binding and piRNA profiles in Drosophila.

This study identifies DDX39/UAP56 as a molecular switch that regulates human mRNA export through TREX and TREX-2 complexes.

The paper identifies polarity domains in Arabidopsis stomatal lineage cells and their associated proteins using proteomics and structural modeling, revealing their role in cell division and pore formation.

This study identifies Kipferl as a cofactor that recruits Rhino to piRNA clusters by binding DNA motifs and interacting with Rhino's chromodomain, revealing DNA sequence as a determinant of piRNA source loci.

The paper investigates how selfish toxin-antidote elements evade silencing in C. tropicalis by showing maternal mRNA licenses zygotic expression through counteracting piRNAs.

The paper reveals how the piRNA pathway connects to the heterochromatin machinery in Drosophila through SUMOylation of Panoramix and its interaction with Sov.

This study identifies SFiNX, a complex required for Piwi-mediated co-transcriptional silencing in Drosophila, revealing its role in piRNA-guided heterochromatin formation.