Itay Talpir

This study shows that thalamic inputs to the insular cortex update representations of physiological needs like thirst and hunger, and that inhibiting these inputs prevents such updates.

Mice can report optogenetic activation of vagal gut mechanosensory neurons; insular cortex encodes perceptual report and causally affects detection only in a difficult psychophysics task, not simple detection.

This study compares protein language models (pLMs) with simple baselines in combinatorial protein design, finding no consistent advantage for pLMs in predicting or generating superior variants.

This paper introduces LAffAb, a method to co-optimize antibody affinity and stability through combinatorial mutation design, achieving significant affinity gains while maintaining developability.

This study uses unsupervised machine learning to analyze insular cortex activity in mice during goal-directed behaviors, finding stereotyped neuronal manifold dynamics that predict trial outcomes across different motivational states.