Ofir Shorer

CloneTrast uses contrastive learning to infer T-cell clonal niches from single-cell RNA-seq, identifying NK-like niches linked to poor immunotherapy response across cancers.

scXpand detects T-cell clonal expansion in cancer from scRNA-seq without TCR sequencing, showing accuracy across tissues and subtypes.

This study shows that targeting CD38 improves T cell function and restores response to immunotherapy in melanoma models.

This study analyzes T cell clones in cancer patients to identify transcriptional differences linked to response to checkpoint immunotherapy.

The paper identifies metabolic gene signatures associated with response to immune checkpoint blockade therapy using single-cell RNA-seq data.