Aleksandra S. Kostina

Network-enabled drug repurposing identifies lithium to promote cardiomyocyte proliferation

This paper uses a computational framework to identify FDA-approved drugs that can promote cardiomyocyte proliferation, finding lithium as a potential therapeutic but highlighting congenital risks.

A Retinoic Acid:YAP1 signaling axis controls atrial lineage commitment

The paper identifies YAP1 as a non-canonical effector of RA signaling essential for atrial lineage commitment in cardiac progenitor cells.

Self-organizing human heart assembloids with autologous and developmentally relevant cardiac neural crest-derived tissues

This paper develops a human heart assembloid model that recapitulates cardiac neural crest integration and reveals antidepressant effects on cardiac development.