Author

Mengchen Ye

PharmaEssentia Corporation (Taiwan)ORCID 0000-0002-2820-1192Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:genetic perturbation / CRISPR· 2 Organism:human· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Chuanhai ZhangiD· 2 shared Dengbao YangiD· 2 shared Hao ZhuiD· 2 shared Hiroyuki SuzukiiD· 2 shared Jeon LeeiD· 2 shared Jingjing WangiD· 2 shared Jingxuan CheniD· 2 shared Mei-Jung Lin· 2 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

Chuanhai ZhangORCID

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2 papers

Recent·Most cited

Interorganelle competition for linoleic acid underlies steatotic liver pathology

Chuanhai Zhang, Dengbao Yang, Hiroyuki Suzuki, Goncalo DiasdoVale, Jingxuan Chen, Amogh Vaidya, Kamran Melikov, Alexandra E. Swisher, Jingjing Wang, Mengchen Ye, Jin Rong Zhou, Qiyu Zeng, Meijuan Bai, Mei-Jung Lin, Jeon Lee, , Xing Zeng

This study identifies CLSTN3B as a driver of MASLD by promoting LD biogenesis and altering lipid partitioning between LDs and mitochondria, leading to mitochondrial dysfunction and oxidative stress.

bioRxiv · Jan 11, 2026 · PreprintCell Biology

Hepatocyte-specific CLSTN3B ablation impairs lipid droplet maturation and alleviates diet-induced steatohepatitis in mice

Chuanhai Zhang, Dengbao Yang, Hiroyuki Suzuki, Jingxuan Chen, Jingjing Wang, Mengchen Ye, Jin Zhou, Qiyu Zeng, Meijuan Bai, Mei-Jung Lin, Jeon Lee, Hao Zhu, Yujin Hoshida, Xing Zeng

This study shows that CLSTN3B promotes lipid droplet maturation in hepatocytes and that its deletion reduces steatohepatitis in mice, with a positive correlation between CLSTN3B expression and MASLD severity in humans.

bioRxiv · May 20, 2025 · PreprintPhysiology